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Arterioscler Thromb Vasc Biol. 2012 Mar;32(3):756-9. doi: 10.1161/ATVBAHA.111.238113. Epub 2011 Nov 17.

Inhibition of microRNA-29 enhances elastin levels in cells haploinsufficient for elastin and in bioengineered vessels--brief report.

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1
Department of Pharmacology, Yale University School of Medicine, Amistad Research Bldg, 10 Amistad St, New Haven, CT 06520, USA.

Abstract

OBJECTIVE:

The goal of this study was to determine whether antagonizing microRNA (miR)-29 enhances elastin (ELN) levels in cells and tissues lacking ELN.

METHODS AND RESULTS:

miR-29 mimics reduced ELN levels in fibroblasts and smooth muscle cells, whereas miR-29 inhibition increased ELN levels. Antagonism of miR-29 also increased ELN levels in cells from patients haploinsufficient for ELN and in bioengineered human vessels.

CONCLUSION:

miR-29 antagonism may promote increased ELN levels during conditions of ELN deficiencies.

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PMID:
22095981
PMCID:
PMC3288647
DOI:
10.1161/ATVBAHA.111.238113
[Indexed for MEDLINE]
Free PMC Article
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