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Mov Disord. 2012 Feb;27(2):293-6. doi: 10.1002/mds.24012. Epub 2011 Nov 16.

Environmental tobacco smoke and Parkinson's disease.

Author information

1
University of Washington, Department of Environmental and Occupational Health Sciences, Seattle, Washington 98195-7234, USA. ssn@u.washington.edu

Abstract

BACKGROUND:

Parkinson's disease is inversely associated with cigarette smoking, but its relation with passive smoking or environmental tobacco smoke exposure is rarely examined.

METHODS:

Within a case-control study, we assessed the association between Parkinson's disease and living or working with active smokers. Cases were newly diagnosed with idiopathic Parkinson's disease (n = 154) from western Washington State in 2002-2008. Age- and sex-matched controls (n = 173) were neurologically normal and unrelated to cases.

RESULTS:

Compared with never active or passive tobacco smokers, we observed reduced Parkinson's disease risks for ever passive only smokers (OR, 0.34; 95% CI, 0.16-0.73), similar to those for ever active smokers (OR, 0.35; 95% CI, 0.17-0.73). Among persons whose only tobacco smoke exposure was passive smoking at home, risk was inversely associated with years exposed.

CONCLUSIONS:

These observations parallel those well established for active smoking. However, it remains unresolved whether a true protective effect of tobacco smoke, generally detrimental to health, underlies these associations.

PMID:
22095755
PMCID:
PMC3289937
DOI:
10.1002/mds.24012
[Indexed for MEDLINE]
Free PMC Article

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