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Nat Rev Neurosci. 2011 Nov 18;12(12):707-22. doi: 10.1038/nrn3120.

Linking neurodevelopmental and synaptic theories of mental illness through DISC1.

Author information

1
Pfizer Neuroscience, Groton, Connecticut 06437, USA. nick.brandon@pfizer.com

Abstract

Recent advances in our understanding of the underlying genetic architecture of psychiatric disorders has blown away the diagnostic boundaries that are defined by currently used diagnostic manuals. The disrupted in schizophrenia 1 (DISC1) gene was originally discovered at the breakpoint of an inherited chromosomal translocation, which segregates with major mental illnesses. In addition, many biological studies have indicated a role for DISC1 in early neurodevelopment and synaptic regulation. Given that DISC1 is thought to drive a range of endophenotypes that underlie major mental conditions, elucidating the biology of DISC1 may enable the construction of new diagnostic categories for mental illnesses with a more meaningful biological foundation.

PMID:
22095064
PMCID:
PMC3954824
DOI:
10.1038/nrn3120
[Indexed for MEDLINE]
Free PMC Article
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