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J Perinatol. 2012 Aug;32(8):626-30. doi: 10.1038/jp.2011.150. Epub 2011 Nov 17.

Decreased survival in necrotizing enterocolitis is significantly associated with neonatal and maternal blood group: the AB isoagglutinin hypothesis.

Author information

1
Division of Neonatology, Department of Pediatrics, Loyola University Medical Center, Maywood, IL 60153, USA.

Abstract

OBJECTIVE:

To determine the effect of neonatal and maternal blood group on the mortality risk from necrotizing enterocolitis (NEC).

STUDY DESIGN:

Retrospective chart review of all neonates admitted to the neonatal intensive care unit over 24 years. Data on birth date, gestational age, maternal/neonatal blood group, number of transfusions, and survival time (defined as date of birth to date of death/discharge) were collected on those with NEC.

RESULT:

276 neonates with Bell stage II-III NEC were analyzed. AB neonates had a significantly higher risk of mortality from NEC compared with other blood groups (HR 2.87; 95% CI 1.40 to 5.89; P=0.003). Multivariate analysis showed AB blood group to be an independent risk factor for mortality from NEC.

CONCLUSION:

Neonatal and maternal blood groups are significantly associated with a neonate's survival from NEC. The increased mortality of AB neonates may be related to factors such as neonatal blood group antigens and/or transplacental transfer of isoagglutinins.

PMID:
22094489
DOI:
10.1038/jp.2011.150
[Indexed for MEDLINE]

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