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Subcell Biochem. 2012;57:251-89. doi: 10.1007/978-94-007-2561-4_12.

Genome-wide analysis of yeast aging.

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Department of Pathology and the Molecular and Cellular Biology Program, University of Washington, Seattle, WA, 98195-7470, USA,


In the past several decades the budding yeast Saccharomyces cerevisiae has emerged as a prominent model for aging research. The creation of a single-gene deletion collection covering the majority of open reading frames in the yeast genome and advances in genomic technologies have opened yeast research to genome-scale screens for a variety of phenotypes. A number of screens have been performed looking for genes that modify secondary age-associated phenotypes such as stress resistance or growth rate. More recently, moderate-throughput methods for measuring replicative life span and high-throughput methods for measuring chronological life span have allowed for the first unbiased screens aimed at directly identifying genes involved in determining yeast longevity. In this chapter we discuss large-scale life span studies performed in yeast and their implications for research related to the basic biology of aging.

[Indexed for MEDLINE]

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