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Cancer Cell. 2011 Nov 15;20(5):555-6. doi: 10.1016/j.ccr.2011.10.028.

Power cut: inhibiting mitochondrial translation to target leukemia.

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1
Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Abstract

In this issue of Cancer Cell, Skrtic et al. demonstrate that inhibition of mitochondrial ribosomes with tigecycline, a known antimicrobial, selectively kills leukemia cells. This finding highlights the metabolic susceptibility of leukemia cells to mitochondrial translational inhibition and identifies a compound with significant efficacy in an in vivo preclinical model.

PMID:
22094249
DOI:
10.1016/j.ccr.2011.10.028
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