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Drug Discov Today. 2012 Feb;17(3-4):173-81. doi: 10.1016/j.drudis.2011.10.029. Epub 2011 Nov 7.

Biomimetic tissues on a chip for drug discovery.

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1
Division of Immunology, School of Molecular Medical Sciences, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK.

Abstract

Developing biologically relevant models of human tissues and organs is an important enabling step for disease modeling and drug discovery. Recent advances in tissue engineering, biomaterials and microfluidics have led to the development of microscale functional units of such models also referred to as 'organs on a chip'. In this review, we provide an overview of key enabling technologies and highlight the wealth of recent work regarding on-chip tissue models. In addition, we discuss the current challenges and future directions of organ-on-chip development.

PMID:
22094245
PMCID:
PMC3273552
DOI:
10.1016/j.drudis.2011.10.029
[Indexed for MEDLINE]
Free PMC Article

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