Format

Send to

Choose Destination
See comment in PubMed Commons below
FEBS Lett. 2011 Dec 15;585(24):4002-9. doi: 10.1016/j.febslet.2011.11.008. Epub 2011 Nov 13.

Human immunodeficiency virus-1 Rev protein activates hepatitis C virus gene expression by directly targeting the HCV 5'-untranslated region.

Author information

1
State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China.

Abstract

Coinfection with human immunodeficiency virus-1 (HIV-1) and hepatitis C virus (HCV) accelerates hepatitis C disease progression; however, the mechanism underlying this effect is unknown. Here, we investigated the role of HIV-1 in HCV gene expression and the mechanism involved in this regulation. We discovered that HIV-1 Rev protein activates HCV gene expression. We further revealed that Rev binds to the internal loop of the HCV 5'-untranslated region (5'-UTR) to stimulate HCV IRES-mediated translation.

PMID:
22094166
DOI:
10.1016/j.febslet.2011.11.008
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center