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Biochem Biophys Res Commun. 2011 Dec 9;416(1-2):31-8. doi: 10.1016/j.bbrc.2011.10.117. Epub 2011 Nov 10.

miR-125b suppresses the proliferation and migration of osteosarcoma cells through down-regulation of STAT3.

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1
Department of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha 410010, China.

Abstract

There is accumulating evidence that microRNAs are involved in multiple processes in development and tumor progression. Abnormally expressed miR-125b was found to play a fundamental role in several types of cancer; however, whether miR-125b participates in regulating the initiation and progress of osteosarcoma still remains unclear. Here we demonstrate that miR-125b is frequently down-regulated in osteosarcoma samples and human osteosarcoma cell lines. The ectopic restoration of miR-125b expression in human osteosarcoma cells suppresses proliferation and migration in vitro and inhibits tumor formation in vivo. We further identified signal transducer and activator of transcription 3 (STAT3) as the direct and functional downstream target of miR-125b. Interestingly, we discovered that the expression of miR-125b is regulated by STAT3 at the level of transcription. STAT3 binds to the promoter region of miR-125b in vitro and serves as a transactivator. Taken together, our findings point to an important role in the molecular etiology of osteosarcoma and suggest that miR-125b is a potential target in the treatment of osteosarcoma.

PMID:
22093834
DOI:
10.1016/j.bbrc.2011.10.117
[Indexed for MEDLINE]
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