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Int J Paediatr Dent. 2012 Jul;22(4):239-43. doi: 10.1111/j.1365-263X.2011.01199.x. Epub 2011 Nov 17.

Microdontia and hypodontia of premolars and permanent molars in childhood cancer survivors after chemotherapy.

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Department of Pediatric Dentistry, School of Dentistry, Faculty of Health Sciences, Aarhus University, Aarhus C, Denmark.



Adverse long-term general and dental health effects of cancer and cancer therapy during childhood have been reported.


To examine the association between chemotherapy before the age of 8 years and (1): microdontia; (2): hypodontia of premolars and permanent molars.


In The Danish Registry of Childhood Cancer (DBCR), we identified 203 children who met the following inclusion criteria: (1) age below 8 years at the start of treatment; (2) age between 12 to 18 years upon dental examination; (3) had received chemotherapy The exclusion criterion was radiotherapy to the head and neck. A total of 150 children fulfilled the inclusion criteria. As controls, a random sample of 193 age-matched unexposed children was included.


Microdontia was found in a total of 88 teeth in 29 (19.3%) of the 150 children who had been exposed to chemotherapy, while none of the controls had microdontia of premolars or permanent molars (difference: 19.3%; 95% CL: 13.5%; 26.4%). The earlier the exposure, the more frequent was microdontia. We found a total of 27 missing premolars and permanent molars in 14 (9.3%) of the exposed children and a total of 18 missing premolars and permanent molars in 8 (4.1%) of the controls (difference: 5.2%; 95% CL: -0.1%; 11.3%).


The present study confirms findings from previous studies that chemotherapy, especially in very young children, causes microdontia and hypodontia of premolars and permanent molars.

[Indexed for MEDLINE]

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