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Mol Biol Int. 2011;2011:437301. doi: 10.4061/2011/437301. Epub 2011 Apr 7.

MiR-146a in Immunity and Disease.

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1
Institute for Research in Biomedicine, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland.

Abstract

MicroRNAs (miRNAs) are regulatory molecules able to influence all aspects of the biology of a cell. They have been associated with diseases such as cancer, viral infections, and autoimmune diseases, and in recent years, they also emerged as important regulators of immune responses. MiR-146a in particular is rapidly gaining importance as a modulator of differentiation and function of cells of the innate as well as adaptive immunity. Given its importance in regulating key cellular functions, it is not surprising that miR-146a expression was also found dysregulated in different types of tumors. In this paper, we summarize recent progress in understanding the role of miR-146a in innate and adaptive immune responses, as well as in disease.

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