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Radiol Res Pract. 2011;2011:212516. doi: 10.1155/2011/212516. Epub 2011 Jan 13.

Malignant Cerebral Edema following CT Myelogram Using Isovue-M 300 Intrathecal Nonionic Water-Soluble Contrast: A Case Report.

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Department of Neurosurgery, University of Kansas Medical Center, 3901 Rainbow Boulevard MS 3021, Kansas City, KS 66160, USA.


Lumbar myelogram utilizing nonionic contrast is a commonly performed procedure to identify spinal pathology. Complication rates are low. Cerebral edema has been shown to occur following intrathecal injection of ionic contrast; however, no current literature has documented this complication relating to the ubiquitously used nonionic contrast medium. We report a case of a patient who developed malignant cerebral edema following a lumbar myelogram with Isovue-M 300 nonionic water-soluble intrathecal contrast. We believe this is the first reported case of cerebral edema resulting from the use of a nonionic contrast.

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