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Molecules. 2011 Nov 16;16(11):9553-61. doi: 10.3390/molecules16119553.

One-pot synthesis of novel 2,3-dihydro-1H-indazoles.

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1
Department of Chemistry, Berry College, PO Box 495016, Mount Berry, GA 30101, USA. gbreton@berry.edu

Abstract

A copper(I)-mediated one-pot synthesis of 2,3-dihydro-1H-indazole heterocycles has been developed. This synthetic route provides the desired indazoles in moderate to good yields (55%-72%) which are substantially better than those achievable with an alternative two-step reaction sequence. The reaction is tolerant of functionality on the aromatic ring.

PMID:
22089862
DOI:
10.3390/molecules16119553
[Indexed for MEDLINE]
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