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Psychopharmacology (Berl). 2012 Jan;219(2):253-70. doi: 10.1007/s00213-011-2560-5. Epub 2011 Nov 18.

Measuring impulsivity in mice: the five-choice serial reaction time task.

Author information

1
School of Psychology, University of Sussex, Falmer, Brighton, BN1 9QG, UK.

Abstract

RATIONALE:

Mice are useful tools for dissecting genetic and environmental factors in relation to the study of attention and impulsivity. The five-choice serial reaction time task (5CSRTT) paradigm has been well established in rats, but its transferability to mice is less well documented.

OBJECTIVES:

This study aims to summarise the main results of the 5CSRTT in mice, with special focus on impulsivity.

METHODS:

The 5CSRTT can be used to explore aspects of both attentional and inhibitory control mechanisms.

RESULTS:

Different manipulations of the task parameters can lead to different results; adjusting the protocol as a function of the main variable of interest or the standardisation of the protocol to be applied to a large set of strains will be desirable.

CONCLUSIONS:

The 5CSRTT has proven to be a useful tool to investigate impulsivity in mice.

PMID:
22089700
DOI:
10.1007/s00213-011-2560-5
[Indexed for MEDLINE]

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