Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Immunol. 2011 Nov 16;12(12):1143-9. doi: 10.1038/ni.2159.

Programmed necrosis: backup to and competitor with apoptosis in the immune system.

Author information

1
State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China. jhan@xmu.edu.cn

Abstract

Programmed cell death is essential for the development and maintenance of the immune system and its responses to exogenous and endogenous stimuli. Studies have demonstrated that in addition to caspase-dependent apoptosis, necrosis dependent on the kinases RIP1 and RIP3 (also called necroptosis) is a major programmed cell-death pathway in development and immunity. These two programmed cell-death pathways may suppress each other, and necroptosis also serves as an alternative when caspase-dependent apoptosis is inhibited or absent. Here we summarize recent advancements that have identified the molecular mechanisms that underlie necroptosis and explore the mechanisms that regulate the interplay between apoptosis and necroptosis.

PMID:
22089220
DOI:
10.1038/ni.2159
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center