Format

Send to

Choose Destination
J Thorac Oncol. 2012 Feb;7(2):406-11. doi: 10.1097/JTO.0b013e3182398e82.

Predictors of postoperative quality of life after surgery for lung cancer.

Author information

1
Karolinska Institutet, Stockholm, Sweden.

Abstract

INTRODUCTION:

The aim was to analyze the association between selected patient variables and health-related quality of life 6 months after surgery for lung cancer.

METHODS:

In a prospective population-based cohort study, Short Form 36 (SF-36) was used to assess quality of life before and 6 months after surgery for lung cancer. The change in SF-36 summary and subscale scores were used to categorize quality of life in two groups (worse or stable/improved) at 6 months compared with baseline. Logistic regression models adjusting for potential confounding factors were used to analyze the association between patient variables and quality of life 6 months after surgery.

RESULTS:

A baseline SF-36 questionnaire was completed by 249 patients. Nonresponders at 6 months (n = 36) were excluded, and 14 patients who died before 6 months follow-up remained in the study, leaving 213 patients available for analysis. Gender, comorbidity, occurrence of postoperative complications, and tumor stage were not associated with the physical aspect of quality of life 6 months after surgery. The extent of resection, age, and adjuvant therapy was significantly associated with a clinically relevant decline in the SF-36 physical component summary score 6 months postoperatively. No patient variables were predictive of a decline in the mental component summary score.

CONCLUSIONS:

The extent of resection, age, and adjuvant therapy was associated with a clinically relevant decline in the physical aspect of health-related quality of life 6 months after surgery. Further studies are needed to explore possible mechanisms.

PMID:
22089118
DOI:
10.1097/JTO.0b013e3182398e82
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center