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Mucosal Immunol. 2012 Jan;5(1):7-18. doi: 10.1038/mi.2011.55. Epub 2011 Nov 16.

Pulmonary-intestinal cross-talk in mucosal inflammatory disease.

Author information

1
School of Biomedical Sciences and Pharmacy and Hunter Medical Research Institute, The University of Newcastle, NSW, Australia. Simon.Keely@newcastle.edu.au

Abstract

Chronic obstructive pulmonary disease (COPD) and inflammatory bowel diseases (IBDs) are chronic inflammatory diseases of mucosal tissues that affect the respiratory and gastrointestinal tracts, respectively. They share many similarities in epidemiological and clinical characteristics, as well as in inflammatory pathologies. Importantly, both conditions are accompanied by systemic comorbidities that are largely overlooked in both basic and clinical research. Therefore, consideration of these complications may maximize the efficacy of prevention and treatment approaches. Here, we examine both the intestinal involvement in COPD and the pulmonary manifestations of IBD. We also review the evidence for inflammatory organ cross-talk that may drive these associations, and discuss the current frontiers of research into these issues.

PMID:
22089028
PMCID:
PMC3243663
DOI:
10.1038/mi.2011.55
[Indexed for MEDLINE]
Free PMC Article

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