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Clin Cardiol. 1990 Sep;13(9):663-5.

Variant angina due to deficiency of intracellular magnesium.

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Second Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa, Japan.


A 51-year-old man was diagnosed as having variant angina by documentation of typical ST elevation during anginal attack and also by showing coronary arterial spasm (#2 and #12) during hyperventilation on coronary arteriography. Large quantities of calcium blocking agents and nitrates could not improve his symptoms. Lack of intracellular magnesium was suspected from a daily excretion of urine magnesium (5.3 mEq) and magnesium tolerance test (56.7%). After hourly infusion of magnesium sulfate (80 mEq), coronary spasm could not be induced by ergonovine.

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