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Expert Rev Proteomics. 2011 Dec;8(6):775-86. doi: 10.1586/epr.11.64.

Dissecting phosphorylation networks: lessons learned from yeast.

Author information

1
Stanford Genome Technology Center, Department of Biochemistry, Stanford School of Medicine, 855 S. California Avenue, Palo Alto, CA 94304, USA.

Abstract

Protein phosphorylation continues to be regarded as one of the most important post-translational modifications found in eukaryotes and has been implicated in key roles in the development of a number of human diseases. In order to elucidate roles for the 518 human kinases, phosphorylation has routinely been studied using the budding yeast Saccharomyces cerevisiae as a model system. In recent years, a number of technologies have emerged to globally map phosphorylation in yeast. In this article, we review these technologies and discuss how these phosphorylation mapping efforts have shed light on our understanding of kinase signaling pathways and eukaryotic proteomic networks in general.

PMID:
22087660
PMCID:
PMC3262144
DOI:
10.1586/epr.11.64
[Indexed for MEDLINE]
Free PMC Article

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