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Hepat Mon. 2011 Apr;11(4):247-54.

The impact of Hepatitis C virus infection on kidney transplantation outcomes: A systematic review of 18 observational studies: The impact of HCV on renal transplantation.

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1
Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.

Abstract

BACKGROUND:

Hepatitis C virus (HCV) infection occursin 0% to 51% of dialysis patients, and manyHCV-positive patients are urged to undergo kidney transplantation. However, the outcome of renal transplantation in HCV-positive recipients is unknown.

OBJECTIVES:

Our review aimed to address the outcomesof renal transplantation recipients (RTRs)following kidney transplantation.

MATERIALS AND METHODS:

We selected studies that used the adjusted relative risk (aRR) and 95% CI of all-cause mortality and graft loss in HCV-positive compared with HCV-negative RTRs as study endpoints. Cox proportional hazard analysis was usedin all studies to calculate the independent effects of HCV infection on RTR outcomes. Sixteen retrospective cohort studies and 2 clinical trials were selected for our review. Sixteen studies were related to patient survival, and 12 examined graft survival.

RESULTS:

The combined hazard ratio in HCV-infected recipients was 1.69-fold (1.33-1.97, p < 0.0001) and 1.56 times (1.22-2.004, p < 0.0001) greaterthan that of HCV-negative recipients for mortality and graft loss, respectively.

CONCLUSIONS:

Although HCV-infected RTRs have worseoutcomes than HCV-negative RTRs,kidney transplantation is the preferred treatment for patients with HCV infection and end-stage renal disease.

KEYWORDS:

Graft survival; Hepatitis C infection; Kidney transplantation; Mortality; Natural history; Outcome assessment; Patient survival

PMID:
22087151
PMCID:
PMC3206701

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