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Nat Rev Mol Cell Biol. 2011 Nov 16;12(12):787-98. doi: 10.1038/nrm3226.

Tail-anchored membrane protein insertion into the endoplasmic reticulum.

Author information

1
Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK. rhegde@mrc-lmb.cam.ac.uk

Abstract

Membrane proteins are inserted into the endoplasmic reticulum (ER) by two highly conserved parallel pathways. The well-studied co-translational pathway uses signal recognition particle (SRP) and its receptor for targeting and the SEC61 translocon for membrane integration. A recently discovered post-translational pathway uses an entirely different set of factors involving transmembrane domain (TMD)-selective cytosolic chaperones and an accompanying receptor at the ER. Elucidation of the structural and mechanistic basis of this post-translational membrane protein insertion pathway highlights general principles shared between the two pathways and key distinctions unique to each.

PMID:
22086371
PMCID:
PMC3760496
DOI:
10.1038/nrm3226
[Indexed for MEDLINE]
Free PMC Article

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