A lateral flow biosensor for detection of nucleic acids with high sensitivity and selectivity

Chem Commun (Camb). 2012 Jan 7;48(2):236-8. doi: 10.1039/c1cc15878c. Epub 2011 Nov 15.

Abstract

A lateral flow biosensor based on isothermal strand-displacement polymerase reaction and gold nanoparticles has been developed for the visual detection of nucleic acids with a detection limit of 0.01 fM.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Biosensing Techniques / instrumentation*
  • Equipment Design
  • Gold / chemistry*
  • Limit of Detection
  • Molecular Sequence Data
  • Nanoparticles / chemistry*
  • Nucleic Acids / analysis*

Substances

  • Nucleic Acids
  • Gold