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Cancer Invest. 2011 Dec;29(10):655-67. doi: 10.3109/07357907.2011.626479.

Systematic review: generating evidence-based guidelines on the concurrent use of dietary antioxidants and chemotherapy or radiotherapy.

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1
Preferred Staffing Group, Inc., Washington, District of Columbia, USA.

Abstract

The risk-benefit ratio for concurrent use of dietary antioxidants with chemotherapy or radiation therapy is a controversial topic. In this review, the medical literature on concurrent antioxidant use with chemotherapy or radiotherapy was assessed and further steps for generating evidence-based guidelines are suggested. The clinical cancer research community should cooperate and focus new studies on the use of a specific combination of antioxidant and chemotherapy or radiotherapy, and determine optimal doses for a specific cancer setting. Mechanistic studies on the interaction between antioxidants and conventional cancer therapy could lead to novel biomarkers for assessing dose adequacy.

PMID:
22085269
PMCID:
PMC3666569
DOI:
10.3109/07357907.2011.626479
[Indexed for MEDLINE]
Free PMC Article
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