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Clin Microbiol Infect. 2012 Jan;18(1):E1-4. doi: 10.1111/j.1469-0691.2011.03695.x. Epub 2011 Nov 15.

In vitro and in vivo reduced fitness and virulence in ciprofloxacin-resistant Acinetobacter baumannii.

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1
Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville, University Hospital Virgen del Rocío/CSIC/University of Seville, Seville, Spain. ysmani-ibis@us.es; y_smani@hotmail.com

Abstract

Limited data on relative fitness and virulence of antimicrobial-resistant Acinetobacter baumannii are known. We aimed to study the virulence and fitness cost of ciprofloxacin-resistance in A. baumannii (CipR) compared with the susceptible parental wild-type strain (CipS). Human lung epithelial cells were infected with CipS and CipR for 24 h. Competition fitness was monitored in vitro and in vivo in a murine peritoneal sepsis model. We showed that CipR induced less cell death than CipS and CipR growth was slow when in competition with CipS. Altogether, acquisition of ciprofloxacin resistance confers a biological fitness cost and reduces virulence in A. baumannii.

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