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Int J Proteomics. 2010;2010:479571. doi: 10.1155/2010/479571. Epub 2011 Mar 2.

Heat shock proteins in the human eye.

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Department of Ophthalmology, Aalborg Hospital, Aarhus University Hospital, Hobrovej 18-22, 9100 Aalborg, Denmark.


Heat shock proteins (Hsps) are believed to primarily protect and maintain cell viability under stressful conditions such as those occurring during thermal and oxidative challenges chiefly by refolding and stabilizing proteins. Hsps are found throughout the various tissues of the eye where they are thought to confer protection from disease states such as cataract, glaucoma, and cancer. This minireview summarizes the placement, properties, and roles of Hsps in the eye and aims to provide a better comprehension of their function and involvement in ocular disease pathogenesis.

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