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Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):18937-42. doi: 10.1073/pnas.1110988108. Epub 2011 Nov 14.

Differential effects on p53-mediated cell cycle arrest vs. apoptosis by p90.

Author information

1
Institute for Cancer Genetics, Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, 1130 St. Nicholas Avenue, New York, NY 10032, USA.

Abstract

p53 functions as a central node for organizing whether the cell responds to stress with apoptosis or cell cycle arrest; however, the molecular events that lead to apoptotic responses are not completely understood. Here, we identified p90 (also called Coiled-Coil Domain Containing 8) as a unique regulator for p53. p90 has no obvious effects on either the levels of p53 or p53-mediated cell cycle arrest but is specifically required for p53-mediated apoptosis upon DNA damage. Notably, p90 is crucial for Tip60-dependent p53 acetylation at Lys120, therefore facilitating activation of the proapoptotic targets. These studies indicate that p90 is a critical cofactor for p53-mediated apoptosis through promoting Tip60-mediated p53 acetylation.

PMID:
22084066
PMCID:
PMC3223437
DOI:
10.1073/pnas.1110988108
[Indexed for MEDLINE]
Free PMC Article

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