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Methods Mol Biol. 2012;813:45-55. doi: 10.1007/978-1-61779-412-4_3.

Robust optimal design of synthetic biological networks.

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1
Faculty of Biology, Centre for Biological Systems Analysis, University of Freiburg, Freiburg, Germany. dirk.lebiedz@biologie.uni-freiburg.de

Abstract

In engineering, the use of mathematical modeling for design purposes has a long history. Long before any technical realization, a system is planned, simulated, and tested extensively on the computer. In biosciences, however, the application of model-based design before going to the wet lab is still rather rare but has particularly high potential in synthetic biology. We demonstrate exemplarily how mathematical modeling and numerical optimization can be used for the design of a circadian rhythm that is supposed to oscillate robustly with respect to uncertainty in system parameters.

PMID:
22083735
DOI:
10.1007/978-1-61779-412-4_3
[Indexed for MEDLINE]
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