Prospective investigation of nasal mupirocin, hexachlorophene body wash, and systemic antibiotics for prevention of recurrent community-associated methicillin-resistant Staphylococcus aureus infections

Antimicrob Agents Chemother. 2012 Feb;56(2):1084-6. doi: 10.1128/AAC.01608-10. Epub 2011 Nov 14.

Abstract

Recurrent community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) skin infections are an increasingly common problem. However, there are no data on the efficacy of decolonization regimens. We prospectively evaluated 31 patients with recurrent CA-MRSA skin infections who received nasal mupirocin, topical hexachlorophene body wash, and an oral anti-MRSA antibiotic. The mean number of MRSA infections after the intervention decreased significantly from baseline (0.03 versus 0.84 infections/month, P = <0.0001). This regimen appears promising at preventing recurrent CA-MRSA infections.

Publication types

  • Clinical Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Administration, Intranasal
  • Administration, Oral
  • Administration, Topical
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use*
  • Anti-Infective Agents, Local
  • Community-Acquired Infections / drug therapy
  • Community-Acquired Infections / microbiology
  • Community-Acquired Infections / prevention & control*
  • Female
  • Hexachlorophene / administration & dosage
  • Hexachlorophene / pharmacology
  • Hexachlorophene / therapeutic use*
  • Humans
  • Male
  • Methicillin-Resistant Staphylococcus aureus / drug effects*
  • Middle Aged
  • Mupirocin / administration & dosage
  • Mupirocin / pharmacology
  • Mupirocin / therapeutic use*
  • Recurrence
  • Staphylococcal Skin Infections / drug therapy
  • Staphylococcal Skin Infections / microbiology
  • Staphylococcal Skin Infections / prevention & control*
  • Treatment Outcome
  • Young Adult

Substances

  • Anti-Bacterial Agents
  • Anti-Infective Agents, Local
  • Mupirocin
  • Hexachlorophene