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J Am Med Inform Assoc. 2012 Mar-Apr;19(2):202-6. doi: 10.1136/amiajnl-2011-000525. Epub 2011 Nov 10.

The Center for Computational Biology: resources, achievements, and challenges.

Author information

1
Center for Computational Biology, Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095-7334, USA. toga@loni.ucla.edu

Abstract

The Center for Computational Biology (CCB) is a multidisciplinary program where biomedical scientists, engineers, and clinicians work jointly to combine modern mathematical and computational techniques, to perform phenotypic and genotypic studies of biological structure, function, and physiology in health and disease. CCB has developed a computational framework built around the Manifold Atlas, an integrated biomedical computing environment that enables statistical inference on biological manifolds. These manifolds model biological structures, features, shapes, and flows, and support sophisticated morphometric and statistical analyses. The Manifold Atlas includes tools, workflows, and services for multimodal population-based modeling and analysis of biological manifolds. The broad spectrum of biomedical topics explored by CCB investigators include the study of normal and pathological brain development, maturation and aging, discovery of associations between neuroimaging and genetic biomarkers, and the modeling, analysis, and visualization of biological shape, form, and size. CCB supports a wide range of short-term and long-term collaborations with outside investigators, which drive the center's computational developments and focus the validation and dissemination of CCB resources to new areas and scientific domains.

PMID:
22081221
PMCID:
PMC3277626
DOI:
10.1136/amiajnl-2011-000525
[Indexed for MEDLINE]
Free PMC Article

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