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Nat Cell Biol. 2011 Nov 13;13(12):1389-91. doi: 10.1038/ncb2387.

A new cap for kinetochore fibre minus ends.

Author information

1
Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94158, USA.

Abstract

In mitotic spindles, each sister chromatid is directly attached to a spindle pole through microtubule bundles known as kinetochore fibres. Microspherule protein 1 (MCRS1) is now shown to support spindle assembly by localizing to the minus ends of kinetochore fibres and protecting them from depolymerization.

PMID:
22081093
PMCID:
PMC3532025
DOI:
10.1038/ncb2387
[Indexed for MEDLINE]
Free PMC Article

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