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J Clin Invest. 2011 Dec;121(12):4618-21. doi: 10.1172/JCI60001. Epub 2011 Nov 14.

Unraveling the functional implications of GWAS: how T cell protein tyrosine phosphatase drives autoimmune disease.

Author information

1
Division of Rheumatology, Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, UCSF, San Francisco, California, USA.

Abstract

Genome-wide association studies (GWAS) have identified a large number of SNPs that are linked to human autoimmune diseases. However, the functional consequences of most of these genetic variations remain undefined. T cell protein tyrosine phosphatase (TCPTP, which is encoded by PTPN2) is a JAK/STAT and growth factor receptor phosphatase that has been linked to the pathogenesis of type 1 diabetes, rheumatoid arthritis, and Crohn's disease by GWAS. In this issue of the JCI, Wiede and colleagues have generated a T cell-specific deletion of TCPTP and identified a novel role for this phosphatase as a negative regulator of TCR signaling. These data provide new insight as to how noncoding PTPN2 SNPs identified in GWAS could drive human autoimmune diseases.

PMID:
22080861
PMCID:
PMC3226009
DOI:
10.1172/JCI60001
[Indexed for MEDLINE]
Free PMC Article

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