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Cancer Lett. 1990 Oct 8;54(1-2):1-8.

Potential use of D-glucaric acid derivatives in cancer prevention.

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Department of Carcinogenesis, University of Texas M.D. Anderson Cancer Center, Smithville 78957.


There is now growing evidence from animal models for the possible control of different stages of the carcinogenic process by the beta-glucuronidase inhibitor D-glucaro-1,4-lactone and its precursors such as D-glucaric acid salts, D-glucarates. D-Glucaric acid is a natural, non-toxic compound produced in small amounts by mammals, including humans. It was recently found in some vegetables and fruits. D-Glucaro-1,4-lactone and D-glucarate exhibit potent antiproliferative properties in vivo. Some human subpopulations could have reduced risk of cancer development by ingesting food rich in D-glucaric acid or self-medication with D-glucarates alone or in combination with other chemopreventive agents.

[Indexed for MEDLINE]

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