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Crit Care Med. 2012 Apr;40(4):1171-6. doi: 10.1097/CCM.0b013e3182387d43.

A multicenter mortality prediction model for patients receiving prolonged mechanical ventilation.

Author information

1
Division of Pulmonary and Critical Care Medicine, Cecil B. Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC, USA. scarson@med.unc.edu

Abstract

OBJECTIVE:

Significant deficiencies exist in the communication of prognosis for patients requiring prolonged mechanical ventilation after acute illness, in part because of clinician uncertainty about long-term outcomes. We sought to refine a mortality prediction model for patients requiring prolonged ventilation using a multicentered study design.

DESIGN:

Cohort study.

SETTING:

Five geographically diverse tertiary care medical centers in the United States (California, Colorado, North Carolina, Pennsylvania, and Washington).

PATIENTS:

Two hundred sixty adult patients who received at least 21 days of mechanical ventilation after acute illness.

INTERVENTIONS:

None.

MEASUREMENTS AND MAIN RESULTS:

For the probability model, we included age, platelet count, and requirement for vasopressors and/or hemodialysis, each measured on day 21 of mechanical ventilation, in a logistic regression model with 1-yr mortality as the outcome variable. We subsequently modified a simplified prognostic scoring rule (ProVent score) by categorizing the risk variables (age 18-49, 50-64, and ≥65 yrs; platelet count 0-150 and >150; vasopressors; hemodialysis) in another logistic regression model and assigning points to variables according to β coefficient values. Overall mortality at 1 yr was 48%. The area under the curve of the receiver operator characteristic curve for the primary ProVent probability model was 0.79 (95% confidence interval 0.75-0.81), and the p value for the Hosmer-Lemeshow goodness-of-fit statistic was .89. The area under the curve for the categorical model was 0.77, and the p value for the goodness-of-fit statistic was .34. The area under the curve for the ProVent score was 0.76, and the p value for the Hosmer-Lemeshow goodness-of-fit statistic was .60. For the 50 patients with a ProVent score >2, only one patient was able to be discharged directly home, and 1-yr mortality was 86%.

CONCLUSION:

The ProVent probability model is a simple and reproducible model that can accurately identify patients requiring prolonged mechanical ventilation who are at high risk of 1-yr mortality.

PMID:
22080643
PMCID:
PMC3395423
DOI:
10.1097/CCM.0b013e3182387d43
[Indexed for MEDLINE]
Free PMC Article

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