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Chem Commun (Camb). 2012 Feb 1;48(10):1473-4. doi: 10.1039/c1cc14939c. Epub 2011 Nov 11.

Cell-selective labeling of bacterial proteomes with an orthogonal phenylalanine amino acid reporter.

Author information

1
The Rockefeller University, Laboratory of Chemical Biology and Microbial Pathogenesis, New York, USA.

Abstract

Orthogonal amino acid reporters allow the selective labeling of different cell types in heterogeneous populations through the expression of engineered aminoacyl tRNA synthetases. Here, we demonstrate that para-ethynylphenylalanine (PEP) can be used as an orthogonal amino acid reporter for efficient selective labeling of an intracellular bacterial pathogen during infection.

PMID:
22080199
DOI:
10.1039/c1cc14939c
[Indexed for MEDLINE]

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