Format

Send to

Choose Destination
Psychiatry Res. 2011 Dec 30;194(3):347-353. doi: 10.1016/j.pscychresns.2011.03.010. Epub 2011 Nov 12.

Assessment of white matter abnormalities in paranoid schizophrenia and bipolar mania patients.

Author information

1
The Department of Psychiatry & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China; The Department of Psychiatry,The First Affiliated Hospital of Guangzhou Medical College, Guangzhou, China.
2
The Department of Psychiatry & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
3
MRI center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
4
King's College London, MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK.
5
The Department of Psychiatry & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China; King's College London, Department of Psychiatry and Psychological Medicine, Institute of Psychiatry, London, UK; King's College London, MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK. Electronic address: xuntao26@hotmail.com.

Abstract

White matter abnormalities have been repeatedly reported in both schizophrenia and bipolar disorder (BD) in diffusion tensor imaging (DTI) studies, but the empirical evidence about the diagnostic specificity of white matter abnormalities in these disorders is still limited. This study sought to investigate the alterations in fractional anisotropy (FA) in white matter throughout the entire brain of patients from Chengdu, China with paranoid schizophrenia and bipolar mania. For this purpose, DTI was used to assess white matter integrity in patients with paranoid schizophrenia (n=25) and psychotic bipolar mania (n=18) who had been treated with standard pharmacotherapy for fewer than 5 days at the time of study, as well as in normal controls (n=30). The differences in FA were measured by use of voxel-based analysis. The results show that reduced FA was found in the left posterior corona radiata (PCR) in patients with psychotic bipolar mania and paranoid schizophrenia compared to the controls. Patients with psychotic bipolar mania also showed a significant reduction in FA in right posterior corona radiata and in right anterior thalamic radiation (ATR). A direct comparison between the two patient groups found no significant differences in any regions, and none of the findings were associated with illness duration. Correlation analysis indicated that FA values showed a significant negative correlation with positive symptom scores on the Positive and Negative Syndrome Scale in the left frontal-parietal lobe in the paranoid schizophrenia. It was concluded that common abnormalities in the left PCR might imply an overlap in white matter pathology in the two disorders and might be related to shared risk factors for the two disorders.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center