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Gene. 2012 Jan 15;492(1):1-18. doi: 10.1016/j.gene.2011.10.044. Epub 2011 Nov 3.

Update on Wnt signaling in bone cell biology and bone disease.

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1
Department of Medicine/Endocrine Research Unit, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

Abstract

For more than a decade, Wnt signaling pathways have been the focus of intense research activity in bone biology laboratories because of their importance in skeletal development, bone mass maintenance, and therapeutic potential for regenerative medicine. It is evident that even subtle alterations in the intensity, amplitude, location, and duration of Wnt signaling pathways affects skeletal development, as well as bone remodeling, regeneration, and repair during a lifespan. Here we review recent advances and discrepancies in how Wnt/Lrp5 signaling regulates osteoblasts and osteocytes, introduce new players in Wnt signaling pathways that have important roles in bone development, discuss emerging areas such as the role of Wnt signaling in osteoclastogenesis, and summarize progress made in translating basic studies to clinical therapeutics and diagnostics centered around inhibiting Wnt pathway antagonists, such as sclerostin, Dkk1 and Sfrp1. Emphasis is placed on the plethora of genetic studies in mouse models and genome wide association studies that reveal the requirement for and crucial roles of Wnt pathway components during skeletal development and disease.

PMID:
22079544
PMCID:
PMC3392173
DOI:
10.1016/j.gene.2011.10.044
[Indexed for MEDLINE]
Free PMC Article
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