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Prog Neurobiol. 2012 May;97(2):173-89. doi: 10.1016/j.pneurobio.2011.10.006. Epub 2011 Nov 3.

Neurodegeneration the RNA way.

Author information

1
Department of Molecular and Integrative Physiology, University of Michigan, 4005 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA.

Abstract

The expression, processing, transport and activities of both coding and non-coding RNAs play critical roles in normal neuronal function and differentiation. Over the past decade, these same pathways have come under scrutiny as potential contributors to neurodegenerative disease. Here we focus broadly on the roles of RNA and RNA processing in neurodegeneration. We first discuss a set of "RNAopathies", where non-coding repeat expansions drive pathogenesis through a surprisingly diverse set of mechanisms. We next explore an emerging class of "RNA binding proteinopathies" where redistribution and aggregation of the RNA binding proteins TDP-43 or FUS contribute to a potentially broad range of neurodegenerative disorders. Lastly, we delve into the potential contributions of alterations in both short and long non-coding RNAs to neurodegenerative illness.

PMID:
22079416
PMCID:
PMC3582174
DOI:
10.1016/j.pneurobio.2011.10.006
[Indexed for MEDLINE]
Free PMC Article
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