Format

Send to

Choose Destination
See comment in PubMed Commons below
Psychiatry Res. 2011 Dec 30;194(3):230-234. doi: 10.1016/j.pscychresns.2011.04.007. Epub 2011 Nov 12.

The 5-HT(2A) receptor and serotonin transporter in Asperger's disorder: A PET study with [¹¹C]MDL 100907 and [¹¹C]DASB.

Author information

1
Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY, USA. Electronic address: rg2290@columbia.edu.
2
Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY, USA.
3
Departments of Psychiatry and Radiology, University of Pittsburgh, Pittsburgh, PA, USA.
4
Department of Pediatrics, University of Toronto, Toronto, ON, Canada.
5
Seaver Autism Center for Research and Treatment, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA.
6
Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY, USA; Department of Neurosciences, Imperial College, London, UK.
7
Department of Psychiatry, Montefiore Medical Center, University Hospital of Albert Einstein College of Medicine, Bronx, NY, USA.

Abstract

Evidence from biochemical, imaging, and treatment studies suggest abnormalities of the serotonin system in autism spectrum disorders, in particular in frontolimbic areas of the brain. We used the radiotracers [(11)C]MDL 100907 and [(11)C]DASB to characterize the 5-HT(2A) receptor and serotonin transporter in Asperger's Disorder. Seventeen individuals with Asperger's Disorder (age=34.3 ± 11.1 years) and 17 healthy controls (age=33.0 ± 9.6 years) were scanned with [(11)C]MDL 100907. Of the 17 patients, eight (age=29.7 ± 7.0 years) were also scanned with [¹¹C]DASB, as were eight healthy controls (age=28.7 ± 7.0 years). Patients with Asperger's Disorder and healthy control subjects were matched for age, gender, and ethnicity, and all had normal intelligence. Metabolite-corrected arterial plasma inputs were collected and data analyzed by two-tissue compartment modeling. The primary outcome measure was regional binding potential BP(ND). Neither regional [¹¹C]MDL 100907 BP(ND) nor [¹¹C]DASB BP(ND) was statistically different between the Asperger's and healthy subjects. This study failed to find significant alterations in binding parameters of 5-HT(2A) receptors and serotonin transporters in adult subjects with Asperger's disorder.

PMID:
22079057
PMCID:
PMC3225493
DOI:
10.1016/j.pscychresns.2011.04.007
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center