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Am J Obstet Gynecol. 2012 Feb;206(2):148.e1-7. doi: 10.1016/j.ajog.2011.09.031. Epub 2011 Oct 6.

Perinatal morbidity and risk of hypoxic-ischemic encephalopathy associated with intrapartum sentinel events.

Author information

1
Department of Neonatology, La Paz University Hospital, Madrid, Spain.

Abstract

OBJECTIVE:

To examine perinatal morbidity and rate of hypoxic-ischemic encephalopathy in infants exposed to intrapartum sentinel events.

STUDY DESIGN:

Retrospective cohort study from 2000-2005. Perinatal mortality, perinatal morbidity and rate of hypoxic-ischemic encephalopathy were compared in 3 groups of infants exposed to different risk factors for perinatal asphyxia (sentinel events, nonreassuring fetal status, elective cesarean section).

RESULTS:

Five hundred eighty-six infants were studied. Perinatal mortality was 6% in the sentinel event group and 0.3% in the nonreassuring fetal status group (relative risk, 2.4; 95% confidence interval, 1.95-2.94). Perinatal morbidity was 2-6 times more frequent in infants exposed to sentinel events; the incidence of hypoxic-ischemic encephalopathy was 10%, compared with 2.5% in the nonreassuring fetal status group (relative risk, 1.93; 95% confidence interval, 1.49-2.52). No infant in the elective cesarean section group died, had perinatal morbidity, or developed encephalopathy.

CONCLUSION:

Intrapartum sentinel events are associated with a high incidence of perinatal morbidity and hypoxic-ischemic encephalopathy.

PMID:
22079054
DOI:
10.1016/j.ajog.2011.09.031
[Indexed for MEDLINE]

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