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Cell. 2011 Nov 11;147(4):742-58. doi: 10.1016/j.cell.2011.10.033.

Programmed cell death in animal development and disease.

Author information

1
Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.

Erratum in

  • Cell. 2011 Dec 23;147(7):1640.

Abstract

Programmed cell death (PCD) plays a fundamental role in animal development and tissue homeostasis. Abnormal regulation of this process is associated with a wide variety of human diseases, including immunological and developmental disorders, neurodegeneration, and cancer. Here, we provide a brief historical overview of the field and reflect on the regulation, roles, and modes of PCD during animal development. We also discuss the function and regulation of apoptotic proteins, including caspases, the key executioners of apoptosis, and review the nonlethal functions of these proteins in diverse developmental processes, such as cell differentiation and tissue remodeling. Finally, we explore a growing body of work about the connections between apoptosis, stem cells, and cancer, focusing on how apoptotic cells release a variety of signals to communicate with their cellular environment, including factors that promote cell division, tissue regeneration, and wound healing.

PMID:
22078876
PMCID:
PMC4511103
DOI:
10.1016/j.cell.2011.10.033
[Indexed for MEDLINE]
Free PMC Article

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