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Cell. 2011 Nov 11;147(4):724-7. doi: 10.1016/j.cell.2011.10.021.

Feedback on fat: p62-mTORC1-autophagy connections.

Author information

1
Sanford-Burnham Medical Research Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037, USA. jmoscat@sanfordburnham.org

Abstract

Metabolic homeostasis requires integration of multiple signals and cellular activities. Without this integration, conditions of obesity and diabetes often develop. Recent in vivo studies explore the molecular basis for metabolic homestasis, showing that p62 links autophagy and mTORC1 activation to regulate adipogenesis and energy control.

PMID:
22078874
PMCID:
PMC3290994
DOI:
10.1016/j.cell.2011.10.021
[Indexed for MEDLINE]
Free PMC Article

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