Format

Send to

Choose Destination
BMC Bioinformatics. 2011 Nov 14;12:443. doi: 10.1186/1471-2105-12-443.

SIGNATURE: a workbench for gene expression signature analysis.

Author information

1
Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, TX, USA. jeffrey.t.chang@uth.tmc.edu

Abstract

BACKGROUND:

The biological phenotype of a cell, such as a characteristic visual image or behavior, reflects activities derived from the expression of collections of genes. As such, an ability to measure the expression of these genes provides an opportunity to develop more precise and varied sets of phenotypes. However, to use this approach requires computational methods that are difficult to implement and apply, and thus there is a critical need for intelligent software tools that can reduce the technical burden of the analysis. Tools for gene expression analyses are unusually difficult to implement in a user-friendly way because their application requires a combination of biological data curation, statistical computational methods, and database expertise.

RESULTS:

We have developed SIGNATURE, a web-based resource that simplifies gene expression signature analysis by providing software, data, and protocols to perform the analysis successfully. This resource uses bayesian methods for processing gene expression data coupled with a curated database of gene expression signatures, all carried out within a GenePattern web interface for easy use and access.

CONCLUSIONS:

SIGNATURE is available for public use at http://genepattern.genome.duke.edu/signature/.

PMID:
22078435
PMCID:
PMC3251189
DOI:
10.1186/1471-2105-12-443
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center