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Breast Cancer Res. 2011;13(6):227. doi: 10.1186/bcr2912. Epub 2011 Nov 1.

The microenvironment in breast cancer progression: biology and implications for treatment.

Author information

1
Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, D740C, Boston, MA 02215, USA.

Abstract

Breast cancer comprises a heterogeneous group of malignancies derived from the ductal epithelium. The microenvironment of these cancers is now recognized as a critical participant in tumor progression and therapeutic responses. Recent data demonstrate significant gene expression and epigenetic alterations in cells composing the microenvironment during disease progression, which can be explored as biomarkers and targets for therapy. Indeed, gene expression signatures derived from tumor stroma have been linked to clinical outcomes. There is increasing interest in translating our current understanding of the tumor microenvironment to the development of novel therapies.

PMID:
22078026
PMCID:
PMC3326543
DOI:
10.1186/bcr2912
[Indexed for MEDLINE]
Free PMC Article

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