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Nucleic Acids Res. 2012 Jan;40(Database issue):D901-6. doi: 10.1093/nar/gkr986. Epub 2011 Nov 10.

OGEE: an online gene essentiality database.

Author information

1
European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.

Abstract

OGEE is an Online GEne Essentiality database. Its main purpose is to enhance our understanding of the essentiality of genes. This is achieved by collecting not only experimentally tested essential and non-essential genes, but also associated gene features such as expression profiles, duplication status, conservation across species, evolutionary origins and involvement in embryonic development. We focus on large-scale experiments and complement our data with text-mining results. Genes are organized into data sets according to their sources. Genes with variable essentiality status across data sets are tagged as conditionally essential, highlighting the complex interplay between gene functions and environments. Linked tools allow the user to compare gene essentiality among different gene groups, or compare features of essential genes to non-essential genes, and visualize the results. OGEE is freely available at http://ogeedb.embl.de.

PMID:
22075992
PMCID:
PMC3245054
DOI:
10.1093/nar/gkr986
[Indexed for MEDLINE]
Free PMC Article

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