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Dev Cell. 2011 Nov 15;21(5):808-10. doi: 10.1016/j.devcel.2011.10.021.

Autophagic factors cut to the bone.

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1
Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel.

Abstract

Autophagy is an intracellular membrane-trafficking pathway for the delivery of proteins and organelles to lysosomes for degradation and recycling. DeSelm and coworkers (2011) now describe an essential role for autophagic proteins in the trafficking and fusion of lysosomes at the site of bone resorption: the osteoclast ruffled border.

PMID:
22075143
DOI:
10.1016/j.devcel.2011.10.021
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