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Vaccine. 2012 Jan 5;30(2):425-35. doi: 10.1016/j.vaccine.2011.10.067. Epub 2011 Nov 7.

Time for change? An economic evaluation of integrated cervical screening and HPV immunization programs in Canada.

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Department of Mathematics and Statistics, University of Guelph, Canada.


Many jurisdictions have implemented universal human papillomavirus (HPV) immunization programs in preadolescent females. However, the cost-effectiveness of modified cervical screening guidelines and/or catch-up immunization in older females in Canada has not been evaluated. We conducted a cost-utility analysis of screening and immunization with the bivalent vaccine for the Canadian setting from the Ministry of Health perspective. We used a dynamic model to capture herd immunity and included cross-protection against strains not included in the vaccine. We found that adding catch-up immunization to the current program would be cost-effective, and that combining catch-up immunization with delaying the age at which screening is first initiated could result in cost savings and net health gains.

[Indexed for MEDLINE]

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