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Mar Drugs. 2011;9(10):1840-59. doi: 10.3390/md9101840. Epub 2011 Oct 10.

Antitumor peptides from marine organisms.

Author information

1
Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China. zhenglanhong@126.com

Abstract

The biodiversity of the marine environment and the associated chemical diversity constitute a practically unlimited resource of new antitumor agents in the field of the development of marine bioactive substances. In this review, the progress on studies of antitumor peptides from marine sources is provided. The biological properties and mechanisms of action of different marine peptides are described; information about their molecular diversity is also presented. Novel peptides that induce apoptosis signal pathway, affect the tubulin-microtubule equilibrium and inhibit angiogenesis are presented in association with their pharmacological properties. It is intended to provide useful information for further research in the fields of marine antitumor peptides.

KEYWORDS:

antitumor; marine organisms; peptides

PMID:
22072999
PMCID:
PMC3210608
DOI:
10.3390/md9101840
[Indexed for MEDLINE]
Free PMC Article
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