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Korean J Parasitol. 2011 Sep;49(3):255-63. doi: 10.3347/kjp.2011.49.3.255. Epub 2011 Sep 30.

In vitro effects of some herbs used in Egyptian traditional medicine on viability of protoscolices of hydatid cysts.

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Department of Medical Parasitology, Assiut University, Egypt.


The present work evaluated the effects of alcoholic extracts of salvia (Salvia officinalis), thyme (Thymus vulgaris), and 2 pure compounds (thymol and menthol) on the viability of Echinococcus granulosus protoscolices in vitro. Four different concentrations of each extract (2,500, 1,500, 1,000, and 500 µg/ml) and 3 different concentrations each of thymol and menthol (50, 10, and 1 µg/ml) were used. Concentration of 2,500 µg/ml of both extracts showed a significant protoscolicidal activity on the 6th day. Complete loss of viability of protoscolices occurred with 500 µg/ml concentration of both extracts at day 6 and day 7 post-treatment (PT), respectively. Pure compounds, i.e., menthol and thymol, showed potent effects with 50 µg/ml concentration at day 2 and day 5 PT, respectively. These effects were compared with those of albendazole sulfoxide (800 µg/ml), a commonly used treatment drug for hydatidosis. Krebs-Ringer solution and the hydatid cystic fluid at a ratio of 4:1 was a good preservative solution which kept the protoscolices viable for 15 days.


Echinococcus granulosus; cystic echinococcus; essential oil; menthol; protoscolex; salvia; thyme; thymol

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