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Biochim Biophys Acta. 1990 Aug 27;1050(1-3):104-9.

Complete nucleotide sequence of the group I RNA bacteriophage fr.

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Department of Biochemistry, University of Leiden, The Netherlands.


We report the complete nucleotide sequence of the group I RNA bacteriophage fr. The entire genome consists of 3575 nucleotides, six nucleotides more than the only other sequenced group I representative, MS2. The greatest divergence between these phages occurs in the 5' terminal region of the A gene, while the lysis-replicase gene overlap, the coat gene and the central region of the replicase gene are highly conserved. Overall sequence homology between fr and MS2 is 77%. Here, we present a general comparison between the two phages. In the accompanying paper we use phylogenetic sequence comparison between MS2 and fr to deduce the secondary structure at the 3' untranslated region.

[Indexed for MEDLINE]

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