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Am J Obstet Gynecol. 2011 Sep;205(3):286.e1-5. doi: 10.1016/j.ajog.2011.06.053. Epub 2011 Jun 21.

An initial miscarriage is associated with adverse pregnancy outcomes in the following pregnancy.

Author information

1
Department of Obstetrics and Gynecology, Soroka University Medical Center, Israel.

Abstract

OBJECTIVE:

The objective of the study was to determine whether 1 previous miscarriage is associated with an increased rate of adverse pregnancy outcomes in the following pregnancy.

STUDY DESIGN:

Second pregnancies of women with and without a miscarriage in their initial pregnancy were compared. Multivariable logistic regression models were constructed to control for confounders.

RESULTS:

Of 35,125 singleton deliveries in the second pregnancy, 5777 (16.4%) were of patients with an initial miscarriage. Multivariable analysis showed a significant association between a previous miscarriage and the following adverse pregnancy outcomes including premature rupture of membranes (odds ratio [OR], 2.22; 95% confidence interval [CI], 2.01-2.44), preterm delivery (OR, 1.34; 95% CI, 1.21-1.48), intrauterine growth restriction (OR, 1.24; 95% CI, 1.04-1.47), hypertensive disorders (OR 1.41; 95% CI 1.07-1.85), preeclampsia (OR, 1.63; 95% CI, 1.22-2.18), and cesarean delivery (OR, 1.59; 95% CI, 1.46-1.73). Perinatal mortality was significantly higher among women with an initial miscarriage (1.6% vs 1.0%; P < .001).

CONCLUSION:

An initial miscarriage is independently associated with adverse pregnancy outcomes.

PMID:
22071067
DOI:
10.1016/j.ajog.2011.06.053
[Indexed for MEDLINE]

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